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A 1070722
CAS No. 1384424-80-9
A 1070722 ( —— )
产品货号. M26040 CAS No. 1384424-80-9
A 1070722 是一种有效的选择性 GSK-3 抑制剂，对 GSK-3α (Ki = 0.6 nM) 和 GSK-3β (Ki = 0.6 nM) 具有高亲和力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥510 | 有现货 |
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| 10MG | ￥786 | 有现货 |
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| 25MG | ￥1596 | 有现货 |
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| 50MG | ￥2892 | 有现货 |
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| 100MG | ￥4317 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称A 1070722
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A 1070722 是一种有效的选择性 GSK-3 抑制剂，对 GSK-3α (Ki = 0.6 nM) 和 GSK-3β (Ki = 0.6 nM) 具有高亲和力。
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产品描述A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.(In Vivo):PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain.
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体外实验——
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体内实验——
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同义词——
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通路PI3K/Akt/mTOR signaling
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靶点GSK-3
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受体Thrombin
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研究领域——
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适应症——
化学信息
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CAS Number1384424-80-9
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分子量362.312
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分子式C17H13F3N4O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 83.33 mg/mL (230.00 mM)
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SMILESCOc1ccc2c(NC(=O)Nc3cccc(n3)C(F)(F)F)ccnc2c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.?Francis CW, et al. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30;349(18):1703-12.
